Protein-based therapeutics, specifically monoclonal antibodies (mAbs), have become the focus of pharmaceutical R&D over the last decade. While these biologics offer many possibilities when it comes to treating a variety of diseases, they also present considerable challenges during development. All of these factors combined make manufacturing and delivery of protein-based therapeutics very difficult. If these drugs could be produced at lower viscosities, then a lower volume could be used, making subcutaneous delivery possible; this would also significantly reduce the risk of aggregates. Now, a treatment that typically requires an hour in a clinic could potentially become a simple injection at home. This informative white paper by Althea covers the challenges of crystallization of proteins for therapeutic use and how to preserve efficiency during crystallization. Learn more about a pathway forward for protein crystallization in the white paper below!
Read More →OQSIE: Quality by Design
This Q&A eBook with OQSIE will delve into: three batch validation; regulatory compliance in product development and quality systems; and how to lead an integrated QbD implementation strategy. OQSIE will also be discussing these topics at a Lunch & Learn at Generis’ American Biomanufacturing Summit taking place May 23-24th in San Diego, CA. Read the full ebook in the link below! http://bit.ly/2qJZLiu
Read More →Talk of the Trade: Heliae
Dan Simon, President & CEO of Heliae Tech. Holdings Inc. discusses the last 5 years of the company and creating a platform to grow economically viable algae. Now they are applying it into four basic categories; Therapeutic drugs, Cosmetics, Nutraceuticals and Agriscience. View the full video below!
Read More →Managing Your Cold Supply Chain to Ensure Your Vaccinations Get to Where They’re Needed Most
World Courier is transporting Zika diagnostic test kits to and from South America. Companies trust us to transport and store time- and temperature-sensitive products, and the urgent and sensitive Zika diagnostic test kits are no exception! In the midst of concerns, especially for the well-being of athletes, World Courier’s capability and expertise are another reason to have peace of mind. The Zika virus was a huge fear for the 2016 Olympic summer games in Rio de Janeiro, Brazil. In the white paper below, World Courrier explains the process and challenges of transporting Zika tests for the 2016 Olympic games to ensure the safety of the Olympic athletes and those attending. Take a look at the full white paper below!
Read More →Optimizing Temperature Control for Biopharmaceuticals
This article first appeared in BioPharm International, October 1, Caroline Hroncich Today pharma companies are faced with an ever-changing market that includes increased regulatory challenges, globalization, and heightened competition (1). Biopharma companies are rapidly expanding into emerging markets where there are new opportunities for drug development. Conversely, logistics companies must keep up with the demand, ensuring all storage technology is equipped to retain the safety and efficacy of a drug by the time it reaches the end of its journey. This article by World Courier delves into these relevant industry topics: Common considerations for shipping biopharmaceuticals; Temperature management in extreme climates; Recent advancements; and Looking ahead. Learn more about optimizing temperature control for biopharmaceuticals in the article below!
Read More →Word Press: Five Considerations When Justifying an Investment in ERP
Organizations entering into an ERP project begin their journey by making a business case for ERP. The effort involves determining an expected return on investment, anticipating total costs and fully documenting the business case for investing in a new or upgraded system. This can’t-miss paper makes the case that it is critical to document the business reasons for an investment in ERP. You’ll see the reasons to calculate the expected value to offset the cost. Identifying risk is part of the process, as is putting in plans to mitigate risk. This white paper by Ultra Consultants will identify five considerations to keep in mind when justifying an investment in ERP leveraging Ultra Consultants’ experience in helping manufacturers with this process. View the full white paper below!
Read More →An Interview with Bill Remy, Chairman and CEO, TBM Consulting Group
Bill Remy is Chairman and Chief Executive Officer at TBM Consulting and a member of the Board of Directors. He has 30plus years of leadership experience in general management and manufacturing operations. Bill’s areas of expertise include operational performance improvement through LeanSigma deployment in manufacturing operations, supply chain, product development and project management. He has experience in a broad array of business leadership positions across various industries including aerospace and defense, railway, industrial and agricultural equipment, technology and process automation. Bill returned to TBM in the summer of 2011 after working at Invensys as Vice President, Continuous Improvement. Prior to Invensys, Bill led the initiative Bill returned to TBM in the summer of 2011 after working at Invensys as Vice President, Continuous Improvement. Prior to Invensys, Bill led the initiative. This Q&A eBook with Bill Remy will touch on the ways that technology is transforming the manufacturing and supply chain industries, lean manufacturing, technology investments, and best practices for manufacturing managers. Read the full eBook below!
Read More →Novel Single-Use Systems Allow Faster Powder Transfer and Higher Recovery Rates
Single use powder containment practices are still in their infancy but keeping your product from cross contamination and reducing airborne particulates is important. Understanding how more modern bag designs can increase safety and speed is a concern to the industry. We looked at the ease of fill along with dispensing times and product loss. ILC Dover’s EZ-Biopac shows a 71% decrease in filling times when measured against an industry standard 2D bag. Due to the non-static film we saw an almost 20% reduction in powder discharge times. In addition, it demonstrates a 33.3% improvement in powder recovery showing reduced waste. Choosing the proper containment system can have a significant impact on plant productivity and profitability. This case study by ILC Dover will delve into: the issues of powder handling; the keys to efficient powder transfer and containment; evaluating potential systems; results; and discharge trials. Find out more about ILC Dover’s EZ-Biopac below!
Read More →Q&A eBook with Bossard: How Will Industry 4.0 Impact Your Supply Chain?
Previously many of these technologies were emerging on their own, but not considered collectively. With a recent push toward an integrated approach, the Internet of Things, the focused effort is much more clear. While efforts are being made to allow technologies to be more interchangeable and data non-exclusive, much of the progress thus far has been disjointed…. This Q&A eBook with Bossard, published by the Generis Group, highlights Industry 4.0, the Internet of Things, full inventory transparency, and more! Bossard creates solutions that enable you to achieve higher productivity while helping you to surface your potential. Connect with Bossard at our American Supply Chain Summit taking place April 24-25th in Orlando, FL. Read the full eBook below:
Read More →QReview: Supply Chain News You Can Use
Transportation Impact, a 4-time Inc. 5000 company, comes from humble beginnings. In 2008, Keith Byrd and Travis Burt, both then senior-level managers at UPS, left the world’s largest shipping company after nearly two decades, respectively, to launch their own start-up with the mission of providing clients with the most competitive small package contracts in the country. The QReview is a magazine that highlights Transportation Impact’s Quarterly Review learnings and is filled with supply chain news that delves into specific strategies, statistics, and stories relevant to the supply chain industry. Take a look inside and find out how to overcome market challenges, look for optimization opportunities, and more below! Subscribe to QReview here.
Read More →